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Targeted Allele Detail
Symbol: Maged1tm1.1Urfm
Name: melanoma antigen, family D, 1; targeted mutation 1.1, Olivier De Backer
MGI ID: MGI:4437118
Gene: Maged1  Location: ChrX:94535474-94542025 bp, - strand  Genetic Position: ChrX, 41.56 cM
Germline Transmission:  Earliest citation of germline transmission: J:157604
Parent Cell Line:  E14 (ES Cell)
Strain of Origin:  129P2/OlaHsd
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
Mutation detailsExons 4-12 were floxed, and a floxed neo cassette was placed within intron 3 by homologous recombination. The neo cassette and floxed exons have been removed. Immunoblotting of brain lysates demonstrated that full-length protein was absent in homozygous animals. (J:157604)
View phenotypes and curated references for all genotypes (concatenated display).
In Structures Affected by this Mutation: 2 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Maged1 Mutation:  6 strains or lines available
Original:  J:157604 Bertrand MJ, et al., NRAGE, a p75NTR adaptor protein, is required for developmental apoptosis in vivo. Cell Death Differ. 2008 Dec;15(12):1921-9
All:  6 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
MGI 6.15
The Jackson Laboratory