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Chgbtm1Ribo
Targeted Allele Detail
Nomenclature
Symbol: Chgbtm1Ribo
Name: chromogranin B; targeted mutation 1, Ricardo Borges
MGI ID: MGI:4437075
Gene: Chgb  Location: Chr2:132781278-132795079 bp, + strand  Genetic Position: Chr2, 64.74 cM, cytoband F-G
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:157697
Parent Cell Line:  E14.1 (ES Cell)
Strain of Origin:  129P2/OlaHsd
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation details117 bases of the proximal promoter region and first 29 bases of the coding region are replaced with a targeting vector. The absence of protein expression was confirmed by immunohistochemistry on adrenal glands. (J:157614, J:157697)
Generation of the Chgbtm1Ribo allele
Phenotypes
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Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Chgb Mutation:  10 strains or lines available
References
Original:  J:157697 Diaz-Vera J, et al., Chromogranin B gene ablation reduces the catecholamine cargo and decelerates exocytosis in chromaffin secretory vesicles. J Neurosci. 2010 Jan 20;30(3):950-7
All:  4 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
07/19/2016
MGI 6.04
The Jackson Laboratory