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Targeted Allele Detail
Symbol: Chgbtm1Ribo
Name: chromogranin B; targeted mutation 1, Ricardo Borges
MGI ID: MGI:4437075
Gene: Chgb  Location: Chr2:132781278-132795079 bp, + strand  Genetic Position: Chr2, 64.74 cM, cytoband F-G
Germline Transmission:  Earliest citation of germline transmission: J:157697
Parent Cell Line:  E14.1 (ES Cell)
Strain of Origin:  129P2/OlaHsd
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
Mutation details117 bases of the proximal promoter region and first 29 bases of the coding region are replaced with a targeting vector. The absence of protein expression was confirmed by immunohistochemistry on adrenal glands. (J:157614, J:157697)
Generation of the Chgbtm1Ribo allele
View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Chgb Mutation:  16 strains or lines available
Original:  J:157697 Diaz-Vera J, et al., Chromogranin B gene ablation reduces the catecholamine cargo and decelerates exocytosis in chromaffin secretory vesicles. J Neurosci. 2010 Jan 20;30(3):950-7
All:  5 reference(s)

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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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MGI 6.11
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