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Del(14Trim13-Dleu2)4Rdf
Targeted Allele Detail
Nomenclature
Symbol: Del(14Trim13-Dleu2)4Rdf
Name: deletion, Chr 14, Riccardo Dalla-Favera 4
MGI ID: MGI:4437040
Synonyms: MDR-
Gene: Del(14Trim13-Dleu2)4Rdf  Location: Chr14:61835696-61919822 bp  Genetic Position: Chr14, Syntenic
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:156946
Parent Cell Line:  W9.5/W95 (ES Cell)
Strain of Origin:  129S1/Sv-Oca2+ Tyr+ Kitl+
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intergenic deletion, Intragenic deletion
  Del(14Trim13-Dleu2)4Rdf involves 13 genes/genome features (Gm27928, Gm27845, Gm27747 ...) View all
 
Mutation detailsThe frt-flanked region between Is(14)1Rdf and Is(14)2Rdf and the GFP reporter were removed by Flp mediated recombination. Portions of Trim13, Kcnrg, Mir15a, Mir16-1, and Dleu2 are deleted. (J:156946)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Disease models
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Expression
In Structures Affected by this Mutation: 1 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Del(14Trim13-Dleu2)4Rdf Mutation:  0 strains or lines available
References
Original:  J:156946 Klein U, et al., The DLEU2/miR-15a/16-1 Cluster Controls B Cell Proliferation and Its Deletion Leads to Chronic Lymphocytic Leukemia. Cancer Cell. 2010 Jan 19;17(1):28-40
All:  4 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
05/17/2022
MGI 6.19
The Jackson Laboratory