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Targeted Allele Detail
Symbol: Ctsztm1Thre
Name: cathepsin Z; targeted mutation 1, Thomas Reinheckel
MGI ID: MGI:4436876
Synonyms: Ctsz-
Gene: Ctsz  Location: Chr2:174427493-174439039 bp, - strand  Genetic Position: Chr2, 97.94 cM
Germline Transmission:  Earliest citation of germline transmission: J:157541
Parent Cell Line:  HM-1 (ES Cell)
Strain of Origin:  129P2/OlaHsd-Hprtb-m3
Allele Type:    Targeted (Null/knockout, Reporter)
Mutations:    Insertion, Intragenic deletion
Mutation detailsPart of exon 2, which contains the active site cysteine critical for enzyme activity, and part of intron 3 were deleted by homologous recombination and replaced by a cassette comprising an independent ribosomal entry sequence (IRES), followed by a lacZ reporter gene and a neomycin cassette. Disruption of the gene was confirmed by RT-PCR and Western blot analyses. (J:157541)
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Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Ctsz Mutation:  2 strains or lines available
Original:  J:157541 Sevenich L, et al., Synergistic antitumor effects of combined cathepsin B and cathepsin Z deficiencies on breast cancer progression and metastasis in mice. Proc Natl Acad Sci U S A. 2010 Feb 9;107(6):2497-502
All:  6 reference(s)

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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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MGI 6.01
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