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Nfil3tm1Pbro
Targeted Allele Detail
Nomenclature
Symbol: Nfil3tm1Pbro
Name: nuclear factor, interleukin 3, regulated; targeted mutation 1, Paul B Rothman
MGI ID: MGI:4436769
Gene: Nfil3  Location: Chr13:52967209-52981073 bp, - strand  Genetic Position: Chr13, 27.68 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:156521
Parent Cell Line:  W4 (ES Cell)
Strain of Origin:  129S6/SvEvTac
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsExon 2 was replaced with a neo cassette. The absence of protein expression was confirmed by western blot analysis on IL-4-stimulated splenocytes. (J:156521)
Generation of the Nfil3tm1Pbro allele
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Disease models
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Expression
In Structures Affected by this Mutation: 4 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Nfil3 Mutation:  7 strains or lines available
References
Original:  J:156521 Kashiwada M, et al., IL-4-induced transcription factor NFIL3/E4BP4 controls IgE class switching. Proc Natl Acad Sci U S A. 2010 Jan 12;107(2):821-6
All:  12 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
10/08/2019
MGI 6.14
The Jackson Laboratory