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Targeted Allele Detail
Symbol: Aldh2tm1a(EUCOMM)Wtsi
Name: aldehyde dehydrogenase 2, mitochondrial; targeted mutation 1a, Wellcome Trust Sanger Institute
MGI ID: MGI:4431566
Gene: Aldh2  Location: Chr5:121704090-121731887 bp, - strand  Genetic Position: Chr5, 61.86 cM, cytoband F-G1
Mutant Cell Lines:  EPD0089_4_A10, EPD0089_4_A11, EPD0089_4_B11, EPD0089_4_C10, EPD0089_4_C12, EPD0089_4_D10, EPD0089_4_D12, EPD0089_4_E12, EPD0089_4_F10, EPD0089_4_F11, EPD0089_4_F12, EPD0089_4_G10, EPD0089_4_H11, EPD0089_4_H12
Germline Transmission:  Earliest citation of germline transmission: J:165965
Parent Cell Line:  JM8.F6 (ES Cell)
Strain of Origin:  C57BL/6N
Project Collection: EUCOMM
Allele Type:    Targeted (Conditional ready, Null/knockout, Reporter)
Mutation:    Insertion     Vector: L1L2_gt0
Mutation detailsThe L1L2_gt0 cassette was inserted at position 121716183 of Chromosome 5 upstream of the critical exon(s) (Build GRCm39). The cassette is composed of an FRT flanked lacZ/neomycin sequence followed by a loxP site. An additional loxP site is inserted downstream of the targeted exon(s) at position 121716910. The critical exon(s) is/are thus flanked by loxP sites. A "conditional ready" (floxed) allele can be created by flp recombinase expression in mice carrying this allele. Subsequent cre expression results in a knockout mouse. If cre expression occurs without flp expression, a reporter knockout mouse will be created. Further information on targeting strategies used for this and other IKMC alleles can be found at http://www.informatics.jax.org/mgihome/nomen/IKMC_schematics.shtml (J:155845, J:173534, J:193232)
View phenotypes and curated references for all genotypes (concatenated display).
Disease models
In Structures Affected by this Mutation: 2 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 1 line available
Carrying any Aldh2 Mutation:  29 strains or lines available
Cell line EPD0089_4_F11 was successfully used to make chimeric mice. Germline transmission was accomplished. J:193232
Original:  J:155845 Wellcome Trust Sanger Institute, Alleles produced for the EUCOMM and EUCOMMTools projects by the Wellcome Trust Sanger Institute. MGI Direct Data Submission. 2010;
All:  12 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
MGI 6.20
The Jackson Laboratory