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Targeted Allele Detail
Symbol: Il4/Il13tm1.1Lky
Name: interleukin 13; targeted mutation 1.1, Richard M Locksley
MGI ID: MGI:4431368
Synonyms: 4-13F
Gene: Il13  Location: Chr11:53631324-53634702 bp, - strand  Genetic Position: Chr11, 31.98 cM
Germline Transmission:  Earliest citation of germline transmission: J:157129
Parent Cell Line:  E14 (ES Cell)
Strain of Origin:  129P2/OlaHsd
Allele Type:    Targeted (Conditional ready, No functional change)
Mutation:    Insertion
Mutation detailsA single targeting event was used to insert a floxed Bsd resistance cassette between exon 2 and 3 of Il13 and an frt flanked neo cassette with a 3' loxP site downstream of exon 4 of Il4 . Flp and cre mediated recombination removed the selection cassettes leaving the region between exon 3 of Il13 and exon 4 of Il4 floxed. (J:157129)
Generation of the Il4/Il13tm1.1Lky allele
View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 2 strains available      Cell Lines: 0 lines available
Carrying any Il13 Mutation:  21 strains or lines available
Original:  J:157129 Voehringer D, et al., Efficient generation of long-distance conditional alleles using recombineering and a dual selection strategy in replicate plates. BMC Biotechnol. 2009;9:69
All:  11 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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MGI 6.16
The Jackson Laboratory