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Il4/Il13tm1.1Lky
Targeted Allele Detail
Nomenclature
Symbol: Il4/Il13tm1.1Lky
Name: interleukin 13; targeted mutation 1.1, Richard M Locksley
MGI ID: MGI:4431368
Synonyms: 4-13F
Gene: Il13  Location: Chr11:53631324-53634702 bp, - strand  Genetic Position: Chr11, 31.98 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:157129
Parent Cell Line:  E14 (ES Cell)
Strain of Origin:  129P2/OlaHsd
Mutation
description
Allele Type:    Targeted (Conditional ready, No functional change)
Mutation:    Insertion
 
Mutation detailsA single targeting event was used to insert a floxed Bsd resistance cassette between exon 2 and 3 of Il13 and an frt flanked neo cassette with a 3' loxP site downstream of exon 4 of Il4 . Flp and cre mediated recombination removed the selection cassettes leaving the region between exon 3 of Il13 and exon 4 of Il4 floxed. (J:157129)
Generation of the Il4/Il13tm1.1Lky allele
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 2 strains available      Cell Lines: 0 lines available
Carrying any Il13 Mutation:  21 strains or lines available
References
Original:  J:157129 Voehringer D, et al., Efficient generation of long-distance conditional alleles using recombineering and a dual selection strategy in replicate plates. BMC Biotechnol. 2009;9:69
All:  11 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
04/06/2021
MGI 6.16
The Jackson Laboratory