About   Help   FAQ
Ripk3tm1Xidw
Targeted Allele Detail
Nomenclature
Symbol: Ripk3tm1Xidw
Name: receptor-interacting serine-threonine kinase 3; targeted mutation 1, Xiaodong Wang
MGI ID: MGI:4431195
Gene: Ripk3  Location: Chr14:55784995-55788857 bp, - strand  Genetic Position: Chr14, 28.19 cM, cytoband C1
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:157346
Parent Cell Line:  R1 (ES Cell)
Strain of Origin:  (129X1/SvJ x 129S1/Sv)F1-Kitl+
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsExons 1 through 3 were replaced with a floxed neo cassette. The absence of protein exprerssion was confirmed by western blot analysis on saline- and cerulein-treated mouse embryonic fibroblasts. (J:157346)
Phenotypes
Loading...
View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 1 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Ripk3 Mutation:  22 strains or lines available
References
Original:  J:157346 He S, et al., Receptor interacting protein kinase-3 determines cellular necrotic response to TNF-alpha. Cell. 2009 Jun 12;137(6):1100-11
All:  19 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
03/24/2020
MGI 6.15
The Jackson Laboratory