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Targeted Allele Detail
Symbol: Col1a1tm1(CAG-Sirt1)Dsin
Name: collagen, type I, alpha 1; targeted mutation 1, David Sinclair
MGI ID: MGI:4430570
Synonyms: Col1a1Sirt1-Tg flox-STOP-flox, ColA1flox-STOP-Sirt1, SIRT1STOP
Gene: Col1a1  Location: Chr11:94936224-94953042 bp, + strand  Genetic Position: Chr11, 59.01 cM, cytoband D
Germline Transmission:  Earliest citation of germline transmission: J:134301
Parent Cell Line:  v6.5 (ES Cell)
Strain of Origin:  (C57BL/6 x 129S4/SvJae)F1
Allele Type:    Targeted (Conditional ready, Inserted expressed sequence)
Mutation:    Insertion
Col1a1tm1(CAG-Sirt1)Dsin expresses 1 gene
Mutation detailsThe SIRT1-Tg flox-STOP-flox construct was designed to insert (from 5' to 3') an FRT site, a CMV-IE enhancer/chicken beta-actin/rabbit beta-globin hybrid promoter (CAG; from the pCAGGS vector), a loxP-flanked transcriptional STOP cassette, the mouse sirtuin 1 (Sirt1) cDNA sequence, and a PGK-hygro-polyA sequence (with a second FRT site between the PGK and hygro) into the 3' UTR of the mouse collagen A1 (Col1a1) locus. (J:134301)
View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Col1a1 Mutation:  121 strains or lines available
Original:  J:134301 Firestein R, et al., The SIRT1 deacetylase suppresses intestinal tumorigenesis and colon cancer growth. PLoS One. 2008;3(4):e2020
All:  10 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
MGI 6.14
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