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Esr1tm1.1Scma
Targeted Allele Detail
Nomenclature
Symbol: Esr1tm1.1Scma
Name: estrogen receptor 1 (alpha); targeted mutation 1.1, Stavros C Manolagas
MGI ID: MGI:4430564
Gene: Esr1  Location: Chr10:4611989-5005633 bp, + strand  Genetic Position: Chr10, 2.03 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:156947
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  Not Specified
Mutation
description
Allele Type:    Targeted (Conditional ready, No functional change)
Mutation:    Insertion
 
Mutation detailsExon 3 was floxed and an frt flanked neo cassette was inserted via homologous recombination. Flp mediated recombination then removed the neo cassette. (J:156947)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 2 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Esr1 Mutation:  14 strains or lines available
References
Original:  J:156947 Martin-Millan M, et al., The estrogen receptor-alpha in osteoclasts mediates the protective effects of estrogens on cancellous but not cortical bone. Mol Endocrinol. 2010 Feb;24(2):323-34
All:  4 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
03/31/2020
MGI 6.15
The Jackson Laboratory