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Stk4tm1.1Rjo
Targeted Allele Detail
Nomenclature
Symbol: Stk4tm1.1Rjo
Name: serine/threonine kinase 4; targeted mutation 1.1, Randy L Johnson
MGI ID: MGI:4430536
Gene: Stk4  Location: Chr2:164074113-164155524 bp, + strand  Genetic Position: Chr2, 84.6 cM, cytoband H3
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:156531
Parent Cell Line:  RJ2.2 (ES Cell)
Strain of Origin:  (C57BL/6Brd-Tyrc-Brd x 129S6/SvEvTac)F1
Mutation
description
Allele Type:    Targeted (Conditional ready, No functional change)
Mutation:    Insertion
 
Mutation detailsExons 4 and 5 were floxed and an FRT flanked neo cassette placed in intron 5. The neo cassette was removed by flp-mediated recombination, leaving exons 4 and 5 flanked by loxP sites. (J:156531)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Stk4 Mutation:  18 strains or lines available
References
Original:  J:156531 Lu L, et al., Hippo signaling is a potent in vivo growth and tumor suppressor pathway in the mammalian liver. Proc Natl Acad Sci U S A. 2010 Jan 26;107(4):1437-42
All:  16 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
07/07/2020
MGI 6.15
The Jackson Laboratory