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Foxp3tm7.2Ayr
Targeted Allele Detail
Summary
Symbol: Foxp3tm7.2Ayr
Name: forkhead box P3; targeted mutation 7.2, Alexander Y Rudensky
MGI ID: MGI:4430234
Synonyms: Foxp3deltaCNS3gfp
Gene: Foxp3  Location: ChrX:7445915-7461482 bp, + strand  Genetic Position: ChrX, 3.41 cM
Alliance: Foxp3tm7.2Ayr page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:156942
Parent Cell Line:  R1 (ES Cell)
Strain of Origin:  (129X1/SvJ x 129S1/Sv)F1-Kitl+
Mutation
description
Allele Type:    Targeted (Modified regulatory region, Null/knockout, Reporter)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsTwo loxP sequences flanking conserved non-coding sequence 3 (CNS3 (Rr131)), within intron 3 downstream of the 1st coding exon, as well as an FRT site flanked neomycin resistance gene cassette were inserted by homologous recombination. In addition, an EGFP cassette was inserted in-frame into the first coding exon. The selection cassette and the CNS were removed by flp- and cre-mediated recombination. (J:156942)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Foxp3 Mutation:  55 strains or lines available
References
Original:  J:156942 Zheng Y, et al., Role of conserved non-coding DNA elements in the Foxp3 gene in regulatory T-cell fate. Nature. 2010 Feb 11;463(7282):808-12
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
03/19/2024
MGI 6.23
The Jackson Laboratory