About   Help   FAQ
Celsr1tm1.1Fati
Targeted Allele Detail
Summary
Symbol: Celsr1tm1.1Fati
Name: cadherin, EGF LAG seven-pass G-type receptor 1; targeted mutation 1.1, Fadel Tissir
MGI ID: MGI:4430218
Gene: Celsr1  Location: Chr15:85783130-85918404 bp, - strand  Genetic Position: Chr15, 40.42 cM
Alliance: Celsr1tm1.1Fati page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:157059
Parent Cell Line:  R1 (ES Cell)
Strain of Origin:  (129X1/SvJ x 129S1/Sv)F1-Kitl+
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsA loxP site and a neo cassette within intron 25 and an additional loxP site within intron 29 were added by homologous recombination. Cre-mediated recombination removed the floxed region. Translation of the mutant mRNA is predicted to produce a truncated protein with a scrambled sequence of 15 amino acids and a premature stop. Quantitative RT-PCR showed that transcript level was five fold lower in the mutant than in the wild-type. (J:157059)
Phenotypes
Loading...
View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Mice Carrying this Mutation: 22 assay results
In Structures Affected by this Mutation: 5 anatomical structure(s)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Celsr1 Mutation:  143 strains or lines available
References
Original:  J:157059 Ravni A, et al., Planar cell polarity cadherin Celsr1 regulates skin hair patterning in the mouse. J Invest Dermatol. 2009 Oct;129(10):2507-9
All:  8 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support.
last database update
03/19/2024
MGI 6.23
The Jackson Laboratory