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Celsr1tm1.1Fati
Targeted Allele Detail
Nomenclature
Symbol: Celsr1tm1.1Fati
Name: cadherin, EGF LAG seven-pass G-type receptor 1; targeted mutation 1.1, Fadel Tissir
MGI ID: MGI:4430218
Gene: Celsr1  Location: Chr15:85898758-86033777 bp, - strand  Genetic Position: Chr15, 40.42 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:157059
Parent Cell Line:  R1 (ES Cell)
Strain of Origin:  (129X1/SvJ x 129S1/Sv)F1-Kitl+
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsA loxP site and a neo cassette within intron 25 and an additional loxP site within intron 29 were added by homologous recombination. Cre-mediated recombination removed the floxed region. Translation of the mutant mRNA is predicted to produce a truncated protein with a scrambled sequence of 15 amino acids and a premature stop. Quantitative RT-PCR showed that transcript level was five fold lower in the mutant than in the wild-type. (J:157059)
Phenotypes
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Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Celsr1 Mutation:  44 strains or lines available
References
Original:  J:157059 Ravni A, et al., Planar cell polarity cadherin Celsr1 regulates skin hair patterning in the mouse. J Invest Dermatol. 2009 Oct;129(10):2507-9
All:  4 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
11/29/2016
MGI 6.06
The Jackson Laboratory