Tg(Rho-GUCA1A*Y99C)L53Amd
Transgene Detail
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Symbol: |
Tg(Rho-GUCA1A*Y99C)L53Amd |
Name: |
transgene insertion L53, Alexander M Dizhoor |
MGI ID: |
MGI:4430086 |
Synonyms: |
Y99C GCAP1 |
Transgene: |
Tg(Rho-GUCA1A*Y99C)L53Amd Location: unknown
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Alliance: |
Tg(Rho-GUCA1A*Y99C)L53Amd page
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Strain of Origin: |
C57BL/6 x DBA/2
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Transgene Type: |
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Transgenic (Inserted expressed sequence) |
Mutation: |
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Insertion
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Tg(Rho-GUCA1A*Y99C)L53Amd expresses
1 gene
Transgene expresses:
Organism |
Expressed Gene |
Note |
cattle |
GUCA1A (282243) |
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Mutation details: The mouse promoter drives rod and cone-specific expression of the bovine cDNA containing a mutation that results in an amino acid substitution of cysteine for tyrosine at position 99 (Y99C). This mutation is found in human patients with late-onset retinal dystrophy. Several lines were created (L52, L52H, L53, L36, L39, L128, and L52X). Line L53 exhibit a 3- to 4-fold in expression compared to endogenous levels.
(J:157063)
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View phenotypes and curated references for all genotypes (concatenated display).
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Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available
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Original: |
J:157063 Olshevskaya EV, et al., The Y99C mutation in guanylyl cyclase-activating protein 1 increases intracellular Ca2+ and causes photoreceptor degeneration in transgenic mice. J Neurosci. 2004 Jul 7;24(27):6078-85 |
All: |
4 reference(s) |
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