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Kdrtm1.1Eia
Targeted Allele Detail
Nomenclature
Symbol: Kdrtm1.1Eia
Name: kinase insert domain protein receptor; targeted mutation 1.1, Anne Eichmann
MGI ID: MGI:4429911
Synonyms: vegfr2egfp
Gene: Kdr  Location: Chr5:75932827-75978458 bp, - strand  Genetic Position: Chr5, 40.23 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:156869
Parent Cell Line:  E14TG2a (ES Cell)
Strain of Origin:  129P2/OlaHsd
Mutation
description
Allele Type:    Targeted (Null/knockout, Reporter)
Mutation:    Insertion
 
Mutation detailsAn EGFP reporter followed by poly(A) signal and a loxP-flanked neomycin selection cassette were inserted into the initiation codon within exon 1 of the gene. The floxed selection cassette in the vector was excised by Cre-mediated recombination by transient transfection with a Cre-expressing plasmid in targeted ES cells. The embryos showed a typical vascular pattern of expression. Real-time PCR analysis of hearts isolated from 5 days old mice showed that the expression of the gene in heterozygous mice was reduced to about 50% of wild-type levels. (J:156869)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Kdr Mutation:  10 strains or lines available
References
Original:  J:156869 Xu Y, et al., Neuropilin-2 mediates VEGF-C-induced lymphatic sprouting together with VEGFR3. J Cell Biol. 2010 Jan 11;188(1):115-30
All:  2 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
02/18/2020
MGI 6.14
The Jackson Laboratory