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Stk4tm1.1Yy
Targeted Allele Detail
Nomenclature
Symbol: Stk4tm1.1Yy
Name: serine/threonine kinase 4; targeted mutation 1.1, Yingzi Yang
MGI ID: MGI:4422173
Synonyms: Mst1-, Mst1delta
Gene: Stk4  Location: Chr2:164070322-164155524 bp, + strand  Genetic Position: Chr2, 84.6 cM, cytoband H3
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:156541
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  Not Specified
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsA loxP site was inserted upstream of exon 4 and an frt flanked neo cassette and second loxP site were inserted downstream of exon 5. Cre mediated recombination then removed exons 4 and 5 (encoding the kinase domain) and the neo cassette. Western blot analysis confirmed the absence of protein expression in homozygous embryos. (J:156541)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Stk4 Mutation:  58 strains or lines available
References
Original:  J:156541 Song H, et al., Mammalian Mst1 and Mst2 kinases play essential roles in organ size control and tumor suppression. Proc Natl Acad Sci U S A. 2010 Jan 8;
All:  5 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
07/11/2017
MGI 6.10
The Jackson Laboratory