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Grntm1.1Aidi
Targeted Allele Detail
Nomenclature
Symbol: Grntm1.1Aidi
Name: granulin; targeted mutation 1.1, Aihao Ding
MGI ID: MGI:4421705
Gene: Grn  Location: Chr11:102430322-102436809 bp, + strand  Genetic Position: Chr11, 66.29 cM
Exaggerated tissue inflammation in Grntm1.1Aidi/Grntm1.1Aidi mice after infection with L. monocytogenes

Show the 3 phenotype image(s) involving this allele.

Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:156824
Parent Cell Line:  C2J (ES Cell)
Strain of Origin:  B6(Cg)-Tyrc-2J/J
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsCre mediated recombination removed exons 1 through 4. The absence of protein expression was confirmed by western blot analysis on bone marrow-derived macrophages. (J:156824)
Generation of the Grntm1Aidi and Grntm1.1Aidi alleles
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Disease models
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Expression
In Structures Affected by this Mutation: 10 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Grn Mutation:  31 strains or lines available
References
Original:  J:156824 Yin F, et al., Exaggerated inflammation, impaired host defense, and neuropathology in progranulin-deficient mice. J Exp Med. 2010 Jan 18;207(1):117-28, S1-4
All:  17 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
07/09/2019
MGI 6.14
The Jackson Laboratory