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Targeted Allele Detail
Symbol: Del(11Nmur2-Sparc)2Anjm
Name: deletion, Chr 11, Andrew N J McKenzie
MGI ID: MGI:4421680
Synonyms: Del(11Nmu2r-Sparc)2Anjm
Gene: Del(11Nmur2-Sparc)2Anjm  Location: unknown  Genetic Position: Chr11, Syntenic
Germline Transmission:  Earliest citation of germline transmission: J:155870
Parent Cell Line:  E14.1 (ES Cell)
Strain of Origin:  129P2/OlaHsd
Allele Type:    Targeted (Null/knockout)
Mutations:    Deletion, Insertion
  Del(11Nmur2-Sparc)2Anjm involves 11 genes/genome features (Gm32012, Sparc, Atox1 ...) View all
Mutation detailsThis deletion was created by cre mediated recombination of loxP sites within Nmur2 (created by random insertion vector of loxP-Puro cassette) and Sparc (created by eliminating exon 6 and replacing it with a Neo-LoxP as well as inserting stop codons in all three reading-frames). The deletion spans a 0.5 Mb Mb interval between Nmur2 and Sparc and includes Glra1, G3bp1 and Atox1. (J:155870)
View phenotypes and curated references for all genotypes (concatenated display).
Disease models
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Del(11Nmur2-Sparc)2Anjm Mutation:  0 strains or lines available
Original:  J:155870 Barlow JL, et al., A p53-dependent mechanism underlies macrocytic anemia in a mouse model of human 5q- syndrome. Nat Med. 2010 Jan;16(1):59-66
All:  1 reference(s)

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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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MGI 6.12
The Jackson Laboratory