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Targeted Allele Detail
Symbol: Atf7tm1Sis
Name: activating transcription factor 7; targeted mutation 1, Shunsuke Ishii
MGI ID: MGI:4421144
Gene: Atf7  Location: Chr15:102525946-102625464 bp, - strand  Genetic Position: Chr15, 57.66 cM, cytoband F3
Germline Transmission:  Earliest citation of germline transmission: J:156409
Parent Cell Line:  TT2 (ES Cell)
Strain of Origin:  (C57BL/6NCrlj x CBA/JNCrlj)F1
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
Mutation detailsExon 10, which encodes the DNA-binding domain containing the fourth and fifth leucines of the leucine zipper struture, was replaced with a neo cassette. The absence of full-length protein expression and production of a fragment was confirmed by western blot analysis on brain extracts. (J:156409)
View phenotypes for all genotypes (concatenated display).
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Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Atf7 Mutation:  36 strains or lines available
Original:  J:156409 Maekawa T, et al., Social isolation stress induces ATF-7 phosphorylation and impairs silencing of the 5-HT 5B receptor gene. EMBO J. 2010 Jan 6;29(1):196-208
All:  2 reference(s)

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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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MGI 6.06
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