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Ptgs2tm1.1Wls
Targeted Allele Detail
Nomenclature
Symbol: Ptgs2tm1.1Wls
Name: prostaglandin-endoperoxide synthase 2; targeted mutation 1.1, William L Smith
MGI ID: MGI:4420987
Synonyms: delta 18 muCox2
Gene: Ptgs2  Location: Chr1:150100031-150108227 bp, + strand  Genetic Position: Chr1, 63.84 cM, cytoband H1
Hypertoprhy of glomeruli in Ptgs2tm1Unc/Ptgs2tm1Unc mice that is not seen in Ptgs2tm1.1Wls/Ptgs2tm1.1Wls mice

Show the 1 phenotype image(s) involving this allele.

Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:156331
Parent Cell Line:  R1 (ES Cell)
Strain of Origin:  (129X1/SvJ x 129S1/Sv)F1-Kitl+
Mutation
description
Allele Type:    Targeted
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsGenomic sequence that codes for amino acids 595 through 612 was deleted by mutagenesis. A floxed neo cassette was inserted upstream of the modified exon 10. Cre mediated recombination removed the neo cassette. The predicted protein lacks the last 18 C-terminal amino acids. (J:156331)
Generation of the Ptgs2tm1.1Wls allele
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 1 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Ptgs2 Mutation:  46 strains or lines available
References
Original:  J:156331 Wada M, et al., Two pathways for cyclooxygenase-2 protein degradation in vivo. J Biol Chem. 2009 Nov 6;284(45):30742-53
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
08/13/2019
MGI 6.14
The Jackson Laboratory