Tg(tetO-LRRK2)C77Cai
Transgene Detail

Summary

• Symbol: Tg(tetO-LRRK2)C77Cai
• Name: transgene insertion C77, Huaibin Cai
• MGI ID: MGI:4420821
• Synonyms: tetO-LRRK2
• Transgene: Tg(tetO-LRRK2)C77Cai Location: unknown
• Alliance: Tg(tetO-LRRK2)C77Cai page

Transgene origin

• Strain of Origin: C57BL/6J

Transgene description

• Transgene Type: Transgenic (Inducible, Inserted expressed sequence)
• Inducer: doxycycline/tetracycline
• Mutation: Insertion
• Mutation details: A transgenic vector was generated encoding the C-terminal hemagglutinin (HA)-tagged human LRRK2 gene under the control of a tetO promoter. The construct was microinjected into fertilized oocytes, and 5 independent founder lines were generated. Line C77 was analyzed as the low expressing line (LRRK2WT-L). (J:133490, J:156512)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

References

• Original: J:156512 Lin X, et al., Leucine-rich repeat kinase 2 regulates the progression of neuropathology induced by Parkinson's-disease-related mutant alpha-synuclein. Neuron. 2009 Dec 24;64(6):807-27
• All: 3 reference(s)