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Transgene Detail
Symbol: Tg(tetO-LRRK2*G2019S)E3Cai
Name: transgene insertion E3, Huaibin Cai
MGI ID: MGI:4420755
Synonyms: G2019S, LRRK2 G2019S, tetO-LRRK2 G2019S
Transgene: Tg(tetO-LRRK2*G2019S)E3Cai  Location: unknown  
Strain of Origin:  C57BL/6J
Transgene Type:    Transgenic (Humanized sequence, Inducible, Inserted expressed sequence)
Mutation:    Insertion
Tg(tetO-LRRK2*G2019S)E3Cai expresses 1 gene
Mutation detailsA transgenic vector was generated encoding the C-terminal hemagglutinin (HA)-tagged human LRRK2*G2019S mutant gene under control of a tetO promoter. The construct was microinjected into C57BL/6J fertilized oocytes, and three independent lines were generated. Founder mice were bred to C57BL/6J mice to establish the E3 line. (J:133490, J:156512)
View phenotypes and curated references for all genotypes (concatenated display).
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Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Original:  J:156512 Lin X, et al., Leucine-rich repeat kinase 2 regulates the progression of neuropathology induced by Parkinson's-disease-related mutant alpha-synuclein. Neuron. 2009 Dec 24;64(6):807-27
All:  4 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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MGI 6.17
The Jackson Laboratory