Tg(Lfng-LFNG)1Dihz
Transgene Detail

Summary

• Symbol: Tg(Lfng-LFNG)1Dihz
• Name: transgene insertion 1, David Ish-Horowicz
• MGI ID: MGI:4420246
• Synonyms: 5kL-1, Lfng5kb-cLfng
• Transgene: Tg(Lfng-LFNG)1Dihz Location: unknown
• Alliance: Tg(Lfng-LFNG)1Dihz page

Regional and dose-dependent rescue of the Lfng phenotype by transgenic expression in the stripe domain

Show the 3 phenotype image(s) involving this allele.

Transgene origin

• Strain of Origin: (CBA x C57BL/6J)F2

Transgene description

• Transgene Type: Transgenic (Inserted expressed sequence)
• Mutation: Insertion
• Tg(Lfng-LFNG)1Dihz expresses 1 gene
  Transgene expresses:
  

  Organism	Expressed Gene	Note
  chicken	LFNG (395790)

• Mutation details: This transgene consists of a 5 kp fragment encoding the mouse Lfng promoter and a C terminally FLAG tagged chicken LFNG gene. Vector sequence was retained due to a mutation in a restriction site. Eight lines were generated. All 8 lines express the transgene in the same pattern as the endogenous mouse gene. (J:155378)

Schematic of the Tg(Lfng*-LFNG)1Dihz, Tg(Lfng*-LFNG)2Dihz, Tg(Lfng-LFNG)1Dihz and Tg(Lfng-LFNG)2Dihz transgenes

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

References

• Original: J:155378 Stauber M, et al., Differential axial requirements for lunatic fringe and Hes7 transcription during mouse somitogenesis. PLoS One. 2009;4(11):e7996
• All: 2 reference(s)