Rab43^{tm1(KOMP)Wtsi}
Targeted Allele Detail

Summary

• Symbol: Rab43^{tm1(KOMP)Wtsi}
• Name: RAB43, member RAS oncogene family; targeted mutation 1, Wellcome Trust Sanger Institute
• MGI ID: MGI:4419460
• Gene: Rab43 Location: Chr6:87765835-87789146 bp, - strand Genetic Position: Chr6, 39.13 cM, cytoband D2
• IMPC: Rab43 gene page

Mutation origin

• Mutant Cell Lines: EPD0416_3_B11, EPD0416_3_C09, EPD0416_3_C10, EPD0416_3_C11, EPD0416_3_D11, EPD0416_3_D12, EPD0416_3_E10, EPD0416_3_E12, EPD0416_3_F10, EPD0416_3_F12, EPD0416_3_G10, EPD0416_3_G11, EPD0416_3_G12, EPD0416_3_H10, EPD0416_3_H11, EPD0416_3_H12
• Germline Transmission: Unknown
• Parent Cell Line: JM8A3.N1 (ES Cell)
• Strain of Origin: C57BL/6N-A^tm1Brd
• Project Collection: KOMP-CSD

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutations: Insertion, Intragenic deletion Vector: L1L2_Bact_P
• Mutation details: The insertion of the L1L2_Bact_P cassette created a deletion of size 2326 starting at position 87769510 and ending at position 87771836 of Chromosome 6 (Genome Build GRCm39). This deletion results in the removal of functionally critical exon(s). The cassette is composed of an FRT site followed by lacZ sequence and a loxP site. This first loxP site is followed by a neomycin resistance gene under the control of the human beta-actin promoter, SV40 polyA, a second FRT site and a second loxP site. (J:148605, J:173534)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 1 line available
• Carrying any Rab43 Mutation: 10 strains or lines available

References

• Original: J:148605 Wellcome Trust Sanger Institute, Alleles produced for the KOMP project by the Wellcome Trust Sanger Institute. MGI Direct Data Submission. 2009
• All: 2 reference(s)