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Targeted Allele Detail
Symbol: Cttntm1.2Okab
Name: cortactin; targetted mutation 1.2, Shigeo Okabe
MGI ID: MGI:4418949
Gene: Cttn  Location: Chr7:144435733-144471009 bp, - strand  Genetic Position: Chr7, 88.84 cM
Germline Transmission:  Earliest citation of germline transmission: J:155986
Parent Cell Line:  J1 (ES Cell)
Strain of Origin:  129S4/SvJae
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
Mutation detailsA single loxP site was introduced 0.5-kb downstream of Exon 4. A reporter fusion construct containing a FRT site, splice acceptor (derived from 0.6kb upstream of exon 6), the cDNA from exons 6-18, IRES, b-galactosidase-neo, polyA, FRT site and an additional loxP site were inserted within intron 5 by homologous recombination. The reporter construct and exon 5 were removed by flp- and cre- mediated recombination respectively. Western blotting showed absence of protein in fibroblasts. (J:155986)
Generation of the Cttntm1.1Okab and Cttntm1.2Okab alleles
View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Cttn Mutation:  20 strains or lines available
Original:  J:155986 Tanaka S, et al., Generation of cortactin floxed mice and cellular analysis of motility in fibroblasts. Genesis. 2009 Sep;47(9):638-46
All:  1 reference(s)

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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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MGI 6.11
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