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Targeted Allele Detail
Symbol: Cttntm1.2Okab
Name: cortactin; targetted mutation 1.2, Shigeo Okabe
MGI ID: MGI:4418949
Gene: Cttn  Location: Chr7:144435733-144471009 bp, - strand  Genetic Position: Chr7, 88.84 cM
Germline Transmission:  Earliest citation of germline transmission: J:155986
Parent Cell Line:  J1 (ES Cell)
Strain of Origin:  129S4/SvJae
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
Mutation detailsA single loxP site was introduced 0.5-kb downstream of Exon 4. A reporter fusion construct containing a FRT site, splice acceptor (derived from 0.6kb upstream of exon 6), the cDNA from exons 6-18, IRES, b-galactosidase-neo, polyA, FRT site and an additional loxP site were inserted within intron 5 by homologous recombination. The reporter construct and exon 5 were removed by flp- and cre- mediated recombination respectively. Western blotting showed absence of protein in fibroblasts. (J:155986)
View phenotypes for all genotypes (concatenated display).
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Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Cttn Mutation:  17 strains or lines available
Original:  J:155986 Tanaka S, et al., Generation of cortactin floxed mice and cellular analysis of motility in fibroblasts. Genesis. 2009 Sep;47(9):638-46
All:  1 reference(s)

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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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MGI 6.06
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