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Cttntm1.2Okab
Targeted Allele Detail
Nomenclature
Symbol: Cttntm1.2Okab
Name: cortactin; targetted mutation 1.2, Shigeo Okabe
MGI ID: MGI:4418949
Gene: Cttn  Location: Chr7:144435733-144471009 bp, - strand  Genetic Position: Chr7, 88.84 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:155986
Parent Cell Line:  J1 (ES Cell)
Strain of Origin:  129S4/SvJae
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsA single loxP site was introduced 0.5-kb downstream of Exon 4. A reporter fusion construct containing a FRT site, splice acceptor (derived from 0.6kb upstream of exon 6), the cDNA from exons 6-18, IRES, b-galactosidase-neo, polyA, FRT site and an additional loxP site were inserted within intron 5 by homologous recombination. The reporter construct and exon 5 were removed by flp- and cre- mediated recombination respectively. Western blotting showed absence of protein in fibroblasts. (J:155986)
Generation of the Cttntm1.1Okab and Cttntm1.2Okab alleles
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Cttn Mutation:  20 strains or lines available
References
Original:  J:155986 Tanaka S, et al., Generation of cortactin floxed mice and cellular analysis of motility in fibroblasts. Genesis. 2009 Sep;47(9):638-46
All:  1 reference(s)

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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
12/05/2017
MGI 6.11
The Jackson Laboratory