Cyp19a1^tm1.1Shah
Targeted Allele Detail

Summary

• Symbol: Cyp19a1^tm1.1Shah
• Name: cytochrome P450, family 19, subfamily a, polypeptide 1; targeted mutation 1.1, Nirao Shah
• MGI ID: MGI:4418756
• Synonyms: aro^IPIN, aromatase-IPIN
• Gene: Cyp19a1 Location: Chr9:54073221-54175394 bp, - strand Genetic Position: Chr9, 29.49 cM
• Alliance: Cyp19a1^tm1.1Shah page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:156012
• Parent Cell Line: MM13 (ES Cell)
• Strain of Origin: 129S/SvEv

Mutation description

• Allele Type: Targeted (Reporter)
• Mutation: Insertion
• Mutation details: This allele contains an internal ribosome entry site (IRES), a human placental alkaline phosphatase gene, a second IRES, and a nuclear-targeted E. coli nlacZ gene inserted three base pairs 3' of the stop codon of the aromatase gene. The targeting vector also contained a self-excising neomycin resistance cassette (ACN) upstream of the IRES-ALPP-IRES nlacZ. Upon passage through the male germline ACN was deleted, leaving a single loxP site and the IRES-ALPP-IRES-nlacZ construct. (J:79620, J:156012)

Expression

In Mice Carrying this Mutation:

7 assay results

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Cyp19a1 Mutation: 34 strains or lines available

References

• Original: J:156012 Wu MV, et al., Estrogen masculinizes neural pathways and sex-specific behaviors. Cell. 2009 Oct 2;139(1):61-72
• All: 5 reference(s)