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Targeted Allele Detail
Symbol: Ehmt1tm1.1Tara
Name: euchromatic histone methyltransferase 1; targeted mutation 1.1, Alexander Tarakhovsky
MGI ID: MGI:4418563
Synonyms: GLPfl
Gene: Ehmt1  Location: Chr2:24790769-24919609 bp, - strand  Genetic Position: Chr2, 16.73 cM
Germline Transmission:  Earliest citation of germline transmission: J:155739
Parent Cell Line:  E14.1 (ES Cell)
Strain of Origin:  129P2/OlaHsd
Allele Type:    Targeted (Conditional ready, No functional change)
Mutation:    Insertion
Mutation detailsExon 23 was floxed and an FRT-flanked neo cassette was inserted into intron 23 via homologous recombination. The selection cassette was then removed by flp mediated recombination. Cre-mediated recombination results in out-of-frame splicing and nonsense mediated decay of the mutant transcript. (J:155739)
View phenotypes for all genotypes (concatenated display).
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Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Ehmt1 Mutation:  38 strains or lines available
Original:  J:155739 Schaefer A, et al., Control of cognition and adaptive behavior by the GLP/G9a epigenetic suppressor complex. Neuron. 2009 Dec 10;64(5):678-91
All:  3 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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MGI 5.21
The Jackson Laboratory