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Pdcd4tm1.1Tosc
Targeted Allele Detail
Nomenclature
Symbol: Pdcd4tm1.1Tosc
Name: programmed cell death 4; transgene insertion 1.1, Tobias Schmid
MGI ID: MGI:4418524
Synonyms: pdcd4delta2,3
Gene: Pdcd4  Location: Chr19:53892231-53929860 bp, + strand  Genetic Position: Chr19, 48.73 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:132696
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  Not Specified
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsAn frt flanked neomycin cassette with a 5' attached loxP site was inserted in intron 3. An additional loxP site was inserted in intron 1. Exons 2 and 3 of the resulting allele are thus flanked by loxP sites. Mice were crossed to transgenic mice carrying a beta actin-cre to excise exons 2 and 3. This results in a frameshift mutation creating a stop site at codon 16. The resulting mice retain the frt flanked neomycin resistance cassette. (J:132696)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Pdcd4 Mutation:  12 strains or lines available
References
Original:  J:132696 Schmid T, et al., Translation inhibitor Pdcd4 is targeted for degradation during tumor promotion. Cancer Res. 2008 Mar 1;68(5):1254-60
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
09/22/2020
MGI 6.16
The Jackson Laboratory