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Ryr1tm1.1Dhm
Targeted Allele Detail
Nomenclature
Symbol: Ryr1tm1.1Dhm
Name: ryanodine receptor 1, skeletal muscle; targeted mutation 1.1, David H MacLennan
MGI ID: MGI:4418317
Synonyms: Ryr1I4895T, Ryr1IT
Gene: Ryr1  Location: Chr7:29003340-29125151 bp, - strand  Genetic Position: Chr7, 16.94 cM, cytoband A2-B3
Kyphosis, hindlimb paresis and myofiber abnormalities in Ryr1tm1.1Dhm/Ryr1+ mice

Show the 7 phenotype image(s) involving this allele.

Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:127629
Parent Cell Line:  TC1/TC-1 (ES Cell)
Strain of Origin:  129S6/SvEvTac
Mutation
description
Allele Type:    Targeted
Mutations:    Insertion, Nucleotide substitutions
 
Mutation details
Phenotypes
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View phenotypes for all genotypes (concatenated display).
Disease models
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Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Ryr1 Mutation:  4 strains or lines available
References
Original:  J:127629 Zvaritch E, et al., An Ryr1I4895T mutation abolishes Ca2+ release channel function and delays development in homozygous offspring of a mutant mouse line. Proc Natl Acad Sci U S A. 2007 Nov 20;104(47):18537-42
All:  4 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
09/23/2014
MGI 5.19
The Jackson Laboratory