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Phox2btm3Jbr
Targeted Allele Detail
Nomenclature
Symbol: Phox2btm3Jbr
Name: paired-like homeobox 2b; targeted mutation 3, Jean-Francois Brunet
MGI ID: MGI:4418265
Synonyms: Phox2blox
Gene: Phox2b  Location: Chr5:67094405-67099301 bp, - strand  Genetic Position: Chr5, 35.95 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:155885
Parent Cell Line:  CK35 (ES Cell)
Strain of Origin:  129S2/SvPas
Mutation
description
Allele Type:    Targeted (Conditional ready, No functional change)
Mutation:    Insertion
 
Mutation detailsA loxP site was inserted upstream of exon 2 and an frt flanked neo cassette with a 5' loxP site was inserted upstream of exon 2. (J:155885)
Phenotypes
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View phenotypes for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Phox2b Mutation:  7 strains or lines available
References
Original:  J:155885 Dubreuil V, et al., Defective respiratory rhythmogenesis and loss of central chemosensitivity in Phox2b mutants targeting retrotrapezoid nucleus neurons. J Neurosci. 2009 Nov 25;29(47):14836-46
All:  4 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
04/07/2015
MGI 5.21
The Jackson Laboratory