Foxa2^tm1.1Stf
Targeted Allele Detail

Summary

• Symbol: Foxa2^tm1.1Stf
• Name: forkhead box A2; targeted mutation 1.1, Markus Stoffel
• MGI ID: MGI:4417942
• Synonyms: Foxa2T156A^flox
• Gene: Foxa2 Location: Chr2:147884797-147888889 bp, - strand Genetic Position: Chr2, 73.38 cM
• Alliance: Foxa2^tm1.1Stf page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:155391
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutations: Insertion, Nucleotide substitutions
• Mutation details: A floxed neo cassette was inserted upstream of exon 3 and a loxP site followed by a modified exon 3 was inserted downstream of exon 3. The modification results in the amino acid substitution of alanine for threonine at position 156 (T156A). Cre mediated recombination removed the neo cassette. (J:155391)

Expression

In Structures Affected by this Mutation:

3 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Foxa2 Mutation: 26 strains or lines available

References

• Original: J:155391 Silva JP, et al., Regulation of adaptive behaviour during fasting by hypothalamic Foxa2. Nature. 2009 Dec 3;462(7273):646-50
• All: 1 reference(s)