About   Help   FAQ
Due to maintenance, access to MGI may be intermittent 8:00 AM ET Wed, September 18.
Foxa2tm1.1Stf
Targeted Allele Detail
Nomenclature
Symbol: Foxa2tm1.1Stf
Name: forkhead box A2; targeted mutation 1.1, Markus Stoffel
MGI ID: MGI:4417942
Synonyms: Foxa2T156Aflox
Gene: Foxa2  Location: Chr2:148042877-148046969 bp, - strand  Genetic Position: Chr2, 73.38 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:155391
Parent Cell Line:  R1 (ES Cell)
Strain of Origin:  (129X1/SvJ x 129S1/Sv)F1-Kitl+
Mutation
description
Allele Type:    Targeted (Conditional ready, No functional change)
Mutations:    Insertion, Nucleotide substitutions
 
Mutation detailsA floxed neo cassette was inserted upstream of exon 3 and a loxP site followed by a modified exon 3 was inserted downstream of exon 3. The modification results in the amino acid substitution of alanine for threonine at position 156 (T156A). Cre mediated recombination removed the neo cassette. (J:155391)
Phenotypes
Loading...
View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 3 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Foxa2 Mutation:  21 strains or lines available
References
Original:  J:155391 Silva JP, et al., Regulation of adaptive behaviour during fasting by hypothalamic Foxa2. Nature. 2009 Dec 3;462(7273):646-50
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
09/05/2019
MGI 6.14
The Jackson Laboratory