Cr2^tm1.1Jhws
Targeted Allele Detail

Summary

• Symbol: Cr2^tm1.1Jhws
• Name: complement receptor 2; targeted mutation 1.1, John Weiss
• MGI ID: MGI:4417922
• Synonyms: Cr2idelta
• Gene: Cr2 Location: Chr1:194819119-194859024 bp, - strand Genetic Position: Chr1, 98.44 cM
• Alliance: Cr2^tm1.1Jhws page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:155241
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Genomic sequence spanning 1726 bp of intron 1, containing the MH box sequences, was replaced with a self-excising neomycin resistance (neo) cassette. The neo cassette removed itself. RT-PCR analysis confirmed the normal expression of the CR1 and CR2 transcripts. (J:155241)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Cr2 Mutation: 84 strains or lines available

References

• Original: J:155241 Roundy KM, et al., Deletion of putative intronic control sequences does not alter cell or stage specific expression of Cr2. Mol Immunol. 2009 Dec;47(2-3):517-25
• All: 2 reference(s)