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Tnfrsf11atm1.2Pngr
Targeted Allele Detail
Nomenclature
Symbol: Tnfrsf11atm1.2Pngr
Name: tumor necrosis factor receptor superfamily, member 11a, NFKB activator; targeted mutation 1.2, Josef M Penninger
MGI ID: MGI:4415802
Synonyms: rankD, rankdelta
Gene: Tnfrsf11a  Location: Chr1:105780723-105847981 bp, + strand  Genetic Position: Chr1, 49.7 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:155398
Parent Cell Line:  A9 (ES Cell)
Strain of Origin:  (C57BL/6 x 129P2/OlaHsd)F1
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsExons 2 and 3 were removed by cre mediated recombination. The absence of protein expression was confirmed by western blot analysis on CD11c+ splenic dendritic cell extracts. (J:155398)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 2 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Tnfrsf11a Mutation:  24 strains or lines available
References
Original:  J:155398 Hanada R, et al., Central control of fever and female body temperature by RANKL/RANK. Nature. 2009 Nov 26;462(7272):505-9
All:  4 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
09/10/2019
MGI 6.14
The Jackson Laboratory