Tnfrsf11a^tm1.2Pngr
Targeted Allele Detail

Summary

• Symbol: Tnfrsf11a^tm1.2Pngr
• Name: tumor necrosis factor receptor superfamily, member 11a, NFKB activator; targeted mutation 1.2, Josef M Penninger
• MGI ID: MGI:4415802
• Synonyms: rank^D, rank^delta
• Gene: Tnfrsf11a Location: Chr1:105708443-105775709 bp, + strand Genetic Position: Chr1, 49.7 cM
• Alliance: Tnfrsf11a^tm1.2Pngr page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:155398
• Parent Cell Line: A9 (ES Cell)
• Strain of Origin: (C57BL/6 x 129P2/OlaHsd)F1

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Exons 2 and 3 were removed by cre mediated recombination. The absence of protein expression was confirmed by western blot analysis on CD11c+ splenic dendritic cell extracts. (J:155398)

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Tnfrsf11a Mutation: 42 strains or lines available

References

• Original: J:155398 Hanada R, et al., Central control of fever and female body temperature by RANKL/RANK. Nature. 2009 Nov 26;462(7272):505-9
• All: 4 reference(s)