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Targeted Allele Detail
Symbol: Tnfrsf11atm1.1Pngr
Name: tumor necrosis factor receptor superfamily, member 11a, NFKB activator; targeted mutation 1.1, Josef M Penninger
MGI ID: MGI:4415800
Synonyms: rankfloxed
Gene: Tnfrsf11a  Location: Chr1:105780723-105847981 bp, + strand  Genetic Position: Chr1, 49.7 cM
Germline Transmission:  Earliest citation of germline transmission: J:155398
Parent Cell Line:  A9 (ES Cell)
Strain of Origin:  (C57BL/6 x 129P2/OlaHsd)F1
Allele Type:    Targeted (Conditional ready, No functional change)
Mutation:    Insertion
Mutation detailsAn frt and loxP flanked neo cassette was inserted upstream of exon 2 and an additional loxP was inserted downstream of exon 3. Flp mediated recombination removed the neo cassette leaving exons 2 and 3 floxed. (J:155398)
View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Tnfrsf11a Mutation:  24 strains or lines available
Original:  J:155398 Hanada R, et al., Central control of fever and female body temperature by RANKL/RANK. Nature. 2009 Nov 26;462(7272):505-9
All:  11 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
MGI 6.14
The Jackson Laboratory