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Lrp6tm1.2Cjz
Targeted Allele Detail
Summary
Symbol: Lrp6tm1.2Cjz
Name: low density lipoprotein receptor-related protein 6; targeted mutation 1.2, Chengji J Zhou
MGI ID: MGI:4415718
Synonyms: Lrp6floxdel
Gene: Lrp6  Location: Chr6:134423439-134543876 bp, - strand  Genetic Position: Chr6, 65.37 cM
Alliance: Lrp6tm1.2Cjz page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:155250
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  C57BL/6
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsA floxed and FRT flanked PGK-neo cassette was inserted in intron2and an additional loxP site was inserted 5' of exon 2. The targeted region, encompassing exon 2, is 1.7 Kb in size. The FRT flanked PGK-neo cassette was excised by crossing to mice carrying the Tg(ACTFLPe)9205Dym transgene. Exon 2 was then deleted by crossing to mice carrying Tg(CMV-cre)1Cgn. Normal mRNA was not detected by Northern blot or RT-PCR. Protein could not be detected by Western blot. (J:155250)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Mice Carrying this Mutation: 7 assay results
In Structures Affected by this Mutation: 14 anatomical structure(s)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Lrp6 Mutation:  95 strains or lines available
References
Original:  J:155250 Zhou CJ, et al., Generation of Lrp6 conditional gene-targeting mouse line for modeling and dissecting multiple birth defects/congenital anomalies. Dev Dyn. 2009 Aug 3;239(1):318-326
All:  2 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
03/19/2024
MGI 6.23
The Jackson Laboratory