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Syktm1.2Tara
Targeted Allele Detail
Nomenclature
Symbol: Syktm1.2Tara
Name: spleen tyrosine kinase; targeted mutation 1.2, Alexander Tarakhovsky
MGI ID: MGI:4415245
Synonyms: Sykfl
Gene: Syk  Location: Chr13:52583173-52648792 bp, + strand  Genetic Position: Chr13, 27.41 cM, cytoband B-C2
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:115080
Parent Cell Line:  E14.1 (ES Cell)
Strain of Origin:  129P2/OlaHsd
Mutation
description
Allele Type:    Targeted (Conditional ready, No functional change)
Mutation:    Insertion
 
Mutation detailsA loxP site was inserted upstream of exon 1 and a floxed neo cassette was inserted downstream of exon 1. Cre mediated recombination removed the neo cassette leaving exon 1 floxed. (J:115080)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Syk Mutation:  28 strains or lines available
References
Original:  J:115080 Saijo K, et al., Essential role of Src-family protein tyrosine kinases in NF-kappaB activation during B cell development. Nat Immunol. 2003 Mar;4(3):274-9
All:  37 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
03/24/2020
MGI 6.15
The Jackson Laboratory