About   Help   FAQ
Syne1tm1Chen
Targeted Allele Detail
Nomenclature
Symbol: Syne1tm1Chen
Name: spectrin repeat containing, nuclear envelope 1; targeted mutation 1, Ju Chen
MGI ID: MGI:4414823
Synonyms: Nesprin 1f
Gene: Syne1  Location: Chr10:5020203-5550692 bp, - strand  Genetic Position: Chr10, 2.01 cM, cytoband A1
Ultrastructural nuclear abnormalities in Syne1tm1Chen/Syne1tm1Chen Syne2tm1.1ChenSyne2tm1.1Chen Tg(Nkx2-5-cre)9Eno/? cardiomyocytes

Show the 1 phenotype image(s) involving this allele.

Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:155342
Parent Cell Line:  R1 (ES Cell)
Strain of Origin:  (129X1/SvJ x 129S1/Sv)F1-Kitl+
Mutation
description
Allele Type:    Targeted (Conditional ready, No functional change)
Mutation:    Insertion
 
Mutation detailsA loxP site was inserted upstream of the sixteenth from last exon and an frt flanked neo cassette with a 3' loxP site was inserted downstream of this exon. (J:155342)
Phenotypes
Loading...
View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Syne1 Mutation:  26 strains or lines available
References
Original:  J:155342 Zhang J, et al., Nesprin 1 is critical for nuclear positioning and anchorage. Hum Mol Genet. 2010 Jan 15;19(2):329-41
All:  3 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
06/13/2017
MGI 6.10
The Jackson Laboratory