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Targeted Allele Detail
Symbol: Syne1tm1Chen
Name: spectrin repeat containing, nuclear envelope 1; targeted mutation 1, Ju Chen
MGI ID: MGI:4414823
Synonyms: Nesprin 1f
Gene: Syne1  Location: Chr10:5020203-5550692 bp, - strand  Genetic Position: Chr10, 2.01 cM, cytoband A1
Ultrastructural nuclear abnormalities in Syne1tm1Chen/Syne1tm1Chen Syne2tm1.1ChenSyne2tm1.1Chen Tg(Nkx2-5-cre)9Eno/? cardiomyocytes

Show the 1 phenotype image(s) involving this allele.

Germline Transmission:  Earliest citation of germline transmission: J:155342
Parent Cell Line:  R1 (ES Cell)
Strain of Origin:  (129X1/SvJ x 129S1/Sv)F1-Kitl+
Allele Type:    Targeted (Conditional ready, No functional change)
Mutation:    Insertion
Mutation detailsA loxP site was inserted upstream of the sixteenth from last exon and an frt flanked neo cassette with a 3' loxP site was inserted downstream of this exon. (J:155342)
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Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Syne1 Mutation:  19 strains or lines available
Original:  J:155342 Zhang J, et al., Nesprin 1 is critical for nuclear positioning and anchorage. Hum Mol Genet. 2010 Jan 15;19(2):329-41
All:  3 reference(s)

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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
MGI 6.06
The Jackson Laboratory