Syne1^tm1Chen
Targeted Allele Detail

Summary

• Symbol: Syne1^tm1Chen
• Name: spectrin repeat containing, nuclear envelope 1; targeted mutation 1, Ju Chen
• MGI ID: MGI:4414823
• Synonyms: Nesprin 1^f
• Gene: Syne1 Location: Chr10:4970917-5501482 bp, - strand Genetic Position: Chr10, 2.01 cM, cytoband A1
• Alliance: Syne1^tm1Chen page

Ultrastructural nuclear abnormalities in Syne1^tm1Chen/Syne1^tm1Chen Syne2^tm1.1ChenSyne2^tm1.1Chen Tg(Nkx2-5-cre)9Eno/? cardiomyocytes

Show the 1 phenotype image(s) involving this allele.

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:155342
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: A loxP site was inserted upstream of the sixteenth from last exon and an frt flanked neo cassette with a 3' loxP site was inserted downstream of this exon. (J:155342)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Syne1 Mutation: 202 strains or lines available

References

• Original: J:155342 Zhang J, et al., Nesprin 1 is critical for nuclear positioning and anchorage. Hum Mol Genet. 2010 Jan 15;19(2):329-41
• All: 4 reference(s)