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Stk4tm1Dlim
Targeted Allele Detail
Nomenclature
Symbol: Stk4tm1Dlim
Name: serine/threonine kinase 4; targeted mutation 1, Dae-Sik Lim
MGI ID: MGI:4414818
Synonyms: Mst1-
Gene: Stk4  Location: Chr2:164074113-164155524 bp, + strand  Genetic Position: Chr2, 84.6 cM, cytoband H3
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:155001
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  Not Specified
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsA 3.3 kb genomic fragment including exons 3 and 4 was replaced with a pgk-puro resistance cassette via homologous recombination. Western blot and RT-PCR analysis confirmed the absence of expression in homozygous MEFs. (J:155001)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Stk4 Mutation:  18 strains or lines available
References
Original:  J:155001 Oh S, et al., Crucial role for Mst1 and Mst2 kinases in early embryonic development of the mouse. Mol Cell Biol. 2009 Dec;29(23):6309-20
All:  10 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
06/23/2020
MGI 6.15
The Jackson Laboratory