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Targeted Allele Detail
Symbol: Plekhg5tm1.1Jbar
Name: pleckstrin homology domain containing, family G (with RhoGef domain) member 5; targeted mutation 1.1, Jay Baraban
MGI ID: MGI:4414815
Synonyms: Syx-
Gene: Plekhg5  Location: Chr4:152156955-152199857 bp, + strand  Genetic Position: Chr4, 82.86 cM
Germline Transmission:  Earliest citation of germline transmission: J:155152
Parent Cell Line:  R1 (ES Cell)
Strain of Origin:  (129X1/SvJ x 129S1/Sv)F1-Kitl+
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
Mutation detailsLoxP sites flank the catalytic domain contained in exons 9-13. Germline cre expression results in excision of the floxed exons 9-13. Western blot analysis indicates the loss of full length protein. However, a truncated protein is present. (J:155152)
View phenotypes and curated references for all genotypes (concatenated display).
In Structures Affected by this Mutation: 1 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Plekhg5 Mutation:  85 strains or lines available
Original:  J:155152 Garnaas MK, et al., Syx, a RhoA guanine exchange factor, is essential for angiogenesis in Vivo. Circ Res. 2008 Sep 26;103(7):710-6
All:  3 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
MGI 6.17
The Jackson Laboratory