Sptlc2^tm2.1Jia
Targeted Allele Detail

Summary

• Symbol: Sptlc2^tm2.1Jia
• Name: serine palmitoyltransferase, long chain base subunit 2; targeted mutation 2.1, Xian-cheng Jiang
• MGI ID: MGI:4414752
• Synonyms: Sptlc2^Flox
• Gene: Sptlc2 Location: Chr12:87351832-87435129 bp, - strand Genetic Position: Chr12, 41.52 cM, cytoband E
• Alliance: Sptlc2^tm2.1Jia page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:155507
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: C57BL/6

Mutation description

Allele Type: Targeted (Conditional ready, No functional change) Mutation: Insertion Mutation details: A loxP site was inserted upstream of exon 1 and an frt flanked neo cassette with a 5' loxP site was inserted downstream of exon 1. Flp mediated recombination removed the neo cassette leaving exon 1 floxed. (J:155507)

Generation of Sptlc2^tm2.1Jia allele

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Sptlc2 Mutation: 170 strains or lines available

References

• Original: J:155507 Li Z, et al., Liver-specific deficiency of serine palmitoyltransferase subunit 2 decreases plasma sphingomyelin and increases apolipoprotein E levels. J Biol Chem. 2009 Sep 25;284(39):27010-9
• All: 6 reference(s)