Gt(ROSA)26Sortm2(Gli2*)Flng
Targeted Allele Detail
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Symbol: |
Gt(ROSA)26Sortm2(Gli2*)Flng |
Name: |
gene trap ROSA 26, Philippe Soriano; targeted mutation 2, Fanxin Long |
MGI ID: |
MGI:4414671 |
Synonyms: |
Rosa26-deltaNGli2 |
Gene: |
Gt(ROSA)26Sor Location: Chr6:113044389-113054205 bp, - strand Genetic Position: Chr6, 52.73 cM
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Alliance: |
Gt(ROSA)26Sortm2(Gli2*)Flng page
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Germline Transmission: |
Earliest citation of germline transmission:
J:154905
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Parent Cell Line: |
RW-4 (ES Cell)
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Strain of Origin: |
129X1/SvJ
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Allele Type: |
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Targeted (Conditional ready, Constitutively active, Inserted expressed sequence, Reporter) |
Mutation: |
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Insertion
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Gt(ROSA)26Sortm2(Gli2*)Flng expresses
1 gene
Knock-in expresses:
Organism |
Expressed Gene |
Note |
mouse |
Gli2 (MGI:95728) |
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Mutation details: A construct containing a floxed neo cassette with 3 polyadenylation sites, Gli2 cDNA lacking the first 280 N-terminal amino acids, an IRES sequence, and EGFP cDNA was inserted into the locus. Cre mediated recombination is required to obtain expression of the Gli2 cDNA and EGFP.
(J:154905)
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View phenotypes and curated references for all genotypes (concatenated display).
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Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available
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Carrying any Gt(ROSA)26Sor Mutation: |
942 strains or lines available
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Original: |
J:154905 Joeng KS, et al., The Gli2 transcriptional activator is a crucial effector for Ihh signaling in osteoblast development and cartilage vascularization. Development. 2009 Dec;136(24):4177-85 |
All: |
2 reference(s) |
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