Il1rapl1^tm1.1Hesk
Targeted Allele Detail

Summary

• Symbol: Il1rapl1^tm1.1Hesk
• Name: interleukin 1 receptor accessory protein-like 1; targeted mutation 1.1, Henriette Skala
• MGI ID: MGI:4414655
• Gene: Il1rapl1 Location: ChrX:85784476-87159251 bp, - strand Genetic Position: ChrX, 39.89 cM
• Alliance: Il1rapl1^tm1.1Hesk page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:155437
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A loxP site was inserted upstream of exon 5 and a floxed hygro cassete was inserted downstream of exon 5. Cre mediated recombination removed exon 5 and the hygro cassette. Removal of exon 5 results in a frame shift and premature termination at amino acid 186. The absence of protein expression was confirmed by western blot analysis on brain extracts. (J:155437)

Expression

In Structures Affected by this Mutation:

3 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Il1rapl1 Mutation: 16 strains or lines available

References

• Original: J:155437 Gambino F, et al., IL1RAPL1 controls inhibitory networks during cerebellar development in mice. Eur J Neurosci. 2009 Oct;30(8):1476-86
• All: 8 reference(s)