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Tspan12tm1Wye
Targeted Allele Detail
Nomenclature
Symbol: Tspan12tm1Wye
Name: tetraspanin 12; targeted mutation 1, Weilan Ye
MGI ID: MGI:4414643
Gene: Tspan12  Location: Chr6:21771395-21852515 bp, - strand  Genetic Position: Chr6, 8.73 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:154863
Parent Cell Line:  Lex-2 (ES Cell)
Strain of Origin:  129S5/SvEvBrd
Mutation
description
Allele Type:    Targeted (Null/knockout, Reporter)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsThe translation initiation site and a major portion of the first transmembrane spanning domain of exon 3 were replaced with a IRES, beta-geo, and puro cassette. The absence of protein expression was confirmed by western blot analysis on embryo extracts. (J:154863)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Disease models
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Expression
In Structures Affected by this Mutation: 7 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Tspan12 Mutation:  1 strain or line available
References
Original:  J:154863 Junge HJ, et al., TSPAN12 regulates retinal vascular development by promoting Norrin- but not Wnt-induced FZD4/beta-catenin signaling. Cell. 2009 Oct 16;139(2):299-311
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
04/09/2019
MGI 6.13
The Jackson Laboratory