Pla2g10^tm1Kiku
Targeted Allele Detail

Summary

• Symbol: Pla2g10^tm1Kiku
• Name: phospholipase A2, group X; targeted mutation 1, Kiyotaka Kugiyama
• MGI ID: MGI:4412409
• Synonyms: Pla2g10^-, sPLA2-X^-
• Gene: Pla2g10 Location: Chr16:13532921-13548847 bp, - strand Genetic Position: Chr16, 9.5 cM
• Alliance: Pla2g10^tm1Kiku page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:155082
• Parent Cell Line: E14 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Exons 1 and 2 were replaced with a neo cassette. The absence of transcript expression was confirmed by RT-PCR blot analysis on stomach and colon extracts. (J:155082)

Expression

In Structures Affected by this Mutation:

3 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Pla2g10 Mutation: 31 strains or lines available

References

• Original: J:155082 Fujioka D, et al., Reduction in myocardial ischemia/reperfusion injury in group X secretory phospholipase A2-deficient mice. Circulation. 2008 Jun 10;117(23):2977-85
• All: 9 reference(s)