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Targeted Allele Detail
Symbol: Gt(ROSA)26Sortm7(CAG-mCherry,-EGFP/tetX)Dym
Name: gene trap ROSA 26, Philippe Soriano; targeted mutation 7, Susan Dymecki
MGI ID: MGI:4412286
Synonyms: RC::PFtox
Gene: Gt(ROSA)26Sor  Location: Chr6:113067428-113077333 bp, - strand  Genetic Position: Chr6, 52.73 cM
Germline Transmission:  Earliest citation of germline transmission: J:154944
Parent Cell Line:  TC1/TC-1 (ES Cell)
Strain of Origin:  129S6/SvEvTac
Allele Type:    Targeted (Conditional ready, No functional change)
Mutation:    Insertion
Mutation detailsA CAG promoter drives expression of an EGFP/tetanus toxin light chain (tetX) fusion preceded by a floxed STOP signal and an frt flanked mCherry and STOP signal. Cre mediated removal of the first STOP signal is required for expression of mCherry. Cre and Frt mediated recombination are required to remove both STOP signals to allow for expression of the EGFP/tetX fusion. (J:154944)
View phenotypes for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Gt(ROSA)26Sor Mutation:  310 strains or lines available
Original:  J:154944 Kim JC, et al., Linking genetically defined neurons to behavior through a broadly applicable silencing allele. Neuron. 2009 Aug 13;63(3):305-15
All:  3 reference(s)

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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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MGI 6.03
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