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Tg(FXN)YG22Pook
Transgene Detail
Nomenclature
Symbol: Tg(FXN)YG22Pook
Name: transgene insertion YG22, Mark A Pook
MGI ID: MGI:4412181
Synonyms: YG22
Transgene: Tg(FXN)YG22Pook  Location: unknown  
Transgene
origin
Strain of Origin:  CBA x C57BL/6
Transgene
description
Transgene Type:    Transgenic (Humanized sequence, Inserted expressed sequence)
Mutation:    Insertion
 
Tg(FXN)YG22Pook expresses 1 gene
 
Mutation detailsThe transgenic construct consists of a 370kb YAC insert that includes the entire human FXN gene with GAA triplet repeat sequences, and was injected into fertilized CBA X C57BL/6 hybrid fertilized oocytes. Founder line YG22 was generated, showing a reduced transmission rate of 21%, indicating germ-line mosaicism of the transgene, compared to 52% transmission to offspring for founder line YG8. One copy of the FXN gene was detected, and contains a single 190 GAA repeat sequence. (J:91581)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Disease models
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Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 2 strains available      Cell Lines: 0 lines available
Notes
Line YG22 exhibits slightly greater age-related repeat instability than line YG8, with a bias toward repeat expansion.
References
Original:  J:91581 Al-Mahdawi S, et al., GAA repeat instability in Friedreich ataxia YAC transgenic mice. Genomics. 2004 Aug;84(2):301-10
All:  4 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
09/10/2019
MGI 6.14
The Jackson Laboratory