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Transgene Detail
Symbol: Tg(SNCA*A53T)2Nbm
Name: transgene insertion 2, Robert L Nussbaum
MGI ID: MGI:4412066
Synonyms: hSNCAA53T, PAC-Tg(SNCAA53T)
Transgene: Tg(SNCA*A53T)2Nbm  Location: unknown  
Alliance: Tg(SNCA*A53T)2Nbm page
Strain of Origin:  FVB/N
Transgene Type:    Transgenic (Humanized sequence, Inserted expressed sequence)
Mutation:    Insertion
  Tg(SNCA*A53T)2Nbm involves 20 genes/genome features (Ccl9, E230016K23Rik, Ccl6 ...) View all
Tg(SNCA*A53T)2Nbm expresses 1 gene
Mutation detailsTo generate the PAC-Tg(SNCAA53T) transgene, the 146 kb RPCI-1 human male P1 artificial chromosome (PAC) clone 27M07, containing the entire human SNCA (synuclein, alpha (non A4 component of amyloid precursor)) gene and 34 kb of its upstream region, was modified to have the A53T human mutation associated with autosomal dominant Parkinson's disease. The transgene integration site is Chr14:111,885,431-111,915,270 (genome build GRCm38/mm10). The updated copy number estimate for line 2 is ~3 copies as hemizygote (~6 copies as homozygote). Multiple genomic fragments from chromosomes 11, 13 and 14 have co-integrated with the transgene. It is not known if these are translocations or duplications. (J:154972, J:156741)
View phenotypes and curated references for all genotypes (concatenated display).
Disease models
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Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 2 strains available      Cell Lines: 0 lines available
Original:  J:156741 Kuo YM, et al., Extensive enteric nervous system abnormalities in mice transgenic for artificial chromosomes containing Parkinson disease-associated alpha-synuclein gene mutations precede central nervous system changes. Hum Mol Genet. 2010 May 1;19(9):1633-50
All:  3 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
MGI 6.22
The Jackson Laboratory