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Tg(HBB-AR-HBA2,-HBB*)58Rub
Transgene Detail
Nomenclature
Symbol: Tg(HBB-AR-HBA2,-HBB*)58Rub
Name: transgene insertion 58, Edward M Rubin
MGI ID: MGI:4411997
Synonyms: alphabetaS Antilles
Transgene: Tg(HBB-AR-HBA2,-HBB*)58Rub  Location: unknown  
Transgene
origin
Strain of Origin:  Swiss Webster
Transgene
description
Transgene Type:    Transgenic (Humanized sequence, Inserted expressed sequence)
Mutation:    Insertion
 
Tg(HBB-AR-HBA2,-HBB*)58Rub expresses 3 genes
 
Mutation detailsThe 800 bp DNA fragment containing the hypersensitive II region of the human HBB locus control region was used to drive erythroid-specific expression of human HBA2 and human HBB containing the Sickle Antilles mutations (G6V and V23I) in co-injected constructs. Two founders were generated (14 and 58). The line from founder 58 contains 4 copies of the HBA2 expressing construct and 10 copies of the HBB* expressing construct. (J:136653)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Disease models
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Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
References
Original:  J:136653 Rubin EM, et al., Hypoxia-induced in vivo sickling of transgenic mouse red cells. J Clin Invest. 1991 Feb;87(2):639-47
All:  6 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
05/17/2022
MGI 6.19
The Jackson Laboratory