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Targeted Allele Detail
Symbol: Stk3tm1.1Jav
Name: serine/threonine kinase 3; targeted mutation 1.1, Joseph Avruch
MGI ID: MGI:4410616
Synonyms: Mst2-
Gene: Stk3  Location: Chr15:34875499-35155882 bp, - strand  Genetic Position: Chr15, 14.34 cM, cytoband B3.3
Germline Transmission:  Earliest citation of germline transmission: J:153945
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  129 x C57BL/6
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
Mutation detailsLoxP sites were inserted to flank exon 3. A neomycin resistance cassette flanked by Frt sites was inserted in the intron before exon3. Exon 3 was deleted by cre mediated recombination. (J:153945)
View phenotypes and curated references for all genotypes (concatenated display).
In Structures Affected by this Mutation: 1 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Stk3 Mutation:  12 strains or lines available
Original:  J:153945 Zhou D, et al., Mst1 and Mst2 maintain hepatocyte quiescence and suppress hepatocellular carcinoma development through inactivation of the Yap1 oncogene. Cancer Cell. 2009 Nov 6;16(5):425-38
All:  4 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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MGI 6.15
The Jackson Laboratory