About   Help   FAQ
Tg(Ins1-cre/ERT)1Lphi
Transgene Detail
Nomenclature
Symbol: Tg(Ins1-cre/ERT)1Lphi
Name: transgene insertion 1, Louis Philipson
MGI ID: MGI:4410453
Synonyms: MIP-CreER, MIP-Cre/ERT, MIP-CreERT1Lphi
Transgene: Tg(Ins1-cre/ERT)1Lphi  Location: unknown  
Transgene
origin
Strain of Origin:  CD-1
Transgene
description
Transgene Type:    Transgenic (Inducible, Recombinase)
Inducer:    tamoxifen
Mutation:    Insertion
 
Mutation detailsAn 8.3 kb fragment of the mouse insulin promoter (Ins1; from nucleotide -8280 to +12 relative to the transcriptional start site) drives cDNA encoding cre recombinase fused to the mutated mouse estrogen receptor ligand binding domain. A 2.1 kb fragment of the hGH gene was added to function as a transcriptional stop signal. The 12.5 kb construct was purified and microinjected into fertilized pronuclei of CD1 mice. Line 1 was established. (J:169727)
Recombinase
activity
Activity:
 Tissue activity of this recombinase allele
Driver: Ins1     Summary of all recombinase alleles driven by Ins1. Comparative matrix view of recombinase activities
 

Phenotypes
Loading...
View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
References
Original:  J:169727 Wicksteed B, et al., Conditional gene targeting in mouse pancreatic ss-Cells: analysis of ectopic Cre transgene expression in the brain. Diabetes. 2010 Dec;59(12):3090-8
All:  67 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
11/16/2021
MGI 6.17
The Jackson Laboratory